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CONVENTIONAL NANOFIBERS

Conventional nanofibers offer unique physical, mechanical and electrical properties associated with their very high specific surface area, high porosity and small pore size. The average for conventional nanofibers range from tens to hundreds of nanometers. The unique properties associated with nanofiber structure present untold possibilities for use in many different areas and applications – medicine, information technology, consumer goods and high technology.
Conventional nanofibers with a homogenous structure are prepared using electrostatic spinning of polymer solutions (see TECHNOLOGIES). Nanopharma, a.s. can provide nanofiber layers in volumes designated for research and development or for small lot production or mass production.

 

APPLICATIONS
• Medicine - dermatology, regenerative medicine – tissue engineering, barrier fabrics (masks), etc.
• Industry – filtration, insulation materials, battery separators, functional layers for clothing.

MATERIALS
Polyvinyl alcohol (PVA), Polycaprolactone (PCL), Polyhydroxybutyrate (PHB), Polylactide (PLA), Poly(L-lactide) (PLLA), Poly(D-lactide) (PDLA), Poly(D,L-lactide-co-glycolide) (PLGA), Polyethylenoxide (PEO), Poly(L-lactide-co-caprolactone-co-glycolide) (PLCG), Poly(DL-lactide-co-caprolactone) (PDLC), Polydioxanone (PDO), Polyamide (PAD), Polyacrylnitril (PAN), Polyurethane (PUR), Polyvinylpyrrolidone (PVP), Polyvinyl butyral (PVB), Polyimide (PID), Sodium Alginate, Elastin, Collagen, Zein, Hyaluronic acid, Cellulose acetate, Gelatin.


koaxialni nanovlakna 1

 

klasicka nanovlakna 2



COAXIAL NANOFIBERS

Coaxial nanofibers have a core/shell structure prepared using coaxial electrostatic spinning. This technique can be used to incorporate active ingredients such as anesthetics, antibiotics, immunosuppressants, natural substances, growth factors and so on. Active ingredients can be incorporated into the core of a coaxial nanofiber in much higher concentrations than conventional nanofibers.

APPLICATIONS
• dermatology (skin covers),
• surgery (functionalized mesh),
• cosmetics (coaxial nanofibers with added active ingredients),
• drug delivery (immobilizing nanoparticles, controlled release of active ingredients),
• tissue engineering,
• nanofiber structures from various types of polymer materials for experimental purposes.

koaxialni nanovlakna 1

 

Another advantage of coaxial electrostatic spinning is the use of this technology to spin materials that are difficult or impossible to spin in the normal way using electrostatic spinning.
Coaxial nanofibers can be used in a number of areas as composite carriers for controlled delivery and release of active ingredients. Nanopharma, a.s. can prepare and functionalize nanofiber structures upon request to suit customer’s needs.

MATERIALS
With regard to the application, the core and shell of coaxial nanofibers can be combined from the following polymer materials:
Polyvinyl alcohol (PVA), Polycaprolactone (PCL), Polyhydroxybutyrate (PHB), Polylactide (PLA), Poly(L-lactide) (PLLA), Poly(D-lactide) (PDLA), Poly(D,L-lactide-co-glycolide) (PLGA), Polyethylenoxide (PEO), Poly(L-lactide-co-caprolactone-co-glycolide) (PLCG), Poly(DL-lactide-co-caprolactone) (PDLC), Polydioxanone (PDO), Polyamide (PAD), Polyacrylnitril (PAN), Polyurethane (PUR), Polyvinylpyrrolidone (PVP), Polyvinyl butyral (PVB), Polyimide (PID), Sodium alginate, Elastin, Collagen, Zein, Hyaluronic acid, Cellulose acetate, Gelatin.
Active ingredients can be incorporated into the nanofiber core at the customer’s request.

koaxialni nanovlakna 2 



POROUS NANOFIBERS

Nanofibers possess many extraordinary qualities, but the greatest advantage is in their high specific surface area. Besides conventional and coaxial nanofibers, under the right conditions we can make porous nanofibers as well. Porous nanofibers can have a range of uses in various applications, since they have specific surface area many times higher than traditional fibers.

APPLICATIONS
• filtration and similar technical areas,
• tissue engineering – for improved cell proliferation on nanofiber structures,
• drug delivery systems (controlled release of drugs).

MATERIALS
Polycaprolactone (PCL), Poly(L-lactide) (PLLA), Poly(D-lactide) (PDLA).

 

porezni nanovlakna 1

porezni nanovlakna 2



3D STRUCTURES

Nanopharma, a.s. is responding to the current needs in the area of regenerative medicine, which addresses on replacing, repairing and/or improving the function of damaged tissues and organs. Tissue engineering, which falls under regenerative medicine, requires cell scaffolds that serve as support structures for cell growth. Given the size of the cells, nanofibers have proven useful for making scaffolds, where the diameters in nanometers and high specific surface area of the fibers are a clear advantage. A functional cell carrier must be structurally similar in form to the extracellular matrix so that the environment for cell cultivation and proliferation is as natural as possible. For this reason Nanopharma, a.s. is developing and producing 2D structures as well as 3D cell carriers from biocompatible and biodegradable materials, which have proven themselves useful for cultivating many different types of cells (stem cells, differentiated cells – fibroblasts, osteoblasts, hepatocytes, endothelial cells, etc.)
The shape and properties of 3D nanofiber structures can be designed to the customer’s specifications.

 

3d struktury